Crystallization (Comment) | Organism |
---|---|
crystal structure determination at 2.1 A resolution of the enzyme with a tryptophanyladenylate bound at the active site, cocrystal structure determination at 1.6 A resolution of an active fragment of the enzyme with its cognate amino acid analogue | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Homo sapiens | - |
AMP + diphosphate + L-tryptophan-tRNATrp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P23381 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + L-tryptophan + tRNATrp = AMP + diphosphate + L-tryptophyl-tRNATrp | active site, 2 critical positions for amino acid discrimination | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Homo sapiens | AMP + diphosphate + L-tryptophan-tRNATrp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tryptophanyl-tRNA synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |